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Retatrutide is a triple hormone receptor agonist. While current weight-loss drugs like Wegovy (GLP-1 only) or Mounjaro (GLP-1 and GIP) target one or two pathways, Retatrutide activates three specific metabolic receptors:
GLP-1 (Glucagon-like peptide-1): Slows gastric emptying and signals the brain to reduce appetite.
GIP (Glucose-dependent insulinotropic polypeptide): Enhances insulin secretion and improves how the body breaks down fat.
GCG (Glucagon): Increases energy expenditure (calorie burning) and specifically targets fat stored in the liver.
(Triple-action peptide)
Retatrutide (also known by the developmental code LY3437943) is an experimental “triple agonist” peptide being developed by Eli Lilly and Company. It is considered a potential successor to medications like Tirzepatide (Mounjaro/Zepbound) due to its broader mechanism of action.
Chemical Name: Retatrutide
CAS Number: 2381089-83-2
Molecular Formula: $C_{221}H_{342}N_{46}O_{68}$
Molecular Weight: Approximately 4731.42 g/mol
Format: Typically supplied as a lyophilized (freeze-dried) powder in various strengths (e.g., 5mg, 10mg, or 20mg vials) for reconstitution.
Current Phase: As of early 2026, Retatrutide is in Phase 3 clinical trials. It is not yet FDA-approved for general public use.
Application: It is designed as a once-weekly subcutaneous injection.
Research Focus: It is being studied primarily for the treatment of obesity, type 2 diabetes, and fatty liver disease (MASH/MASLD).