What is Melanotan II (MT-II)?

Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed at the University of Arizona in the 1980s–1990s. It is characterised as a non-selective melanocortin receptor agonist with high affinity for MC1R (Ki 0.67 nM), MC4R (Ki 6.6 nM), MC3R (Ki 34 nM), and MC5R (Ki 46 nM). Its molecular formula is C50H69N15O9 with a molecular weight of approximately 1024.2 g/mol. CAS Number: 121062-08-6. MT-II is the parent compound from which PT-141 (Bremelanotide) was derived. All Sempica supply is strictly for in vitro and laboratory research use only — it is not MHRA-approved in the UK for any human-use indication.

What does the 20mg Melanotan II pack contain?

The Sempica Melanotan II 20mg pack contains 2 x 10mg sealed lyophilised (freeze-dried) vials, providing 20mg total research-grade MT-II. Each vial is independently sealed under controlled conditions to protect against moisture, heat, and light degradation. Both vials are from the same verified synthesis batch and are supplied with a single batch-specific Certificate of Analysis (COA) confirming ≥99% HPLC purity and mass spectrometry verification at 1024.2 g/mol.

What purity is Sempica's Melanotan II 20mg?

Sempica supplies Melanotan II at ≥99% purity, independently verified by HPLC (High-Performance Liquid Chromatography) and mass spectrometry. Each batch COA confirms: HPLC purity results (≥99%), mass spectrometry molecular weight confirmation (1024.2 g/mol), peptide identity verification, and appearance data. The 20mg pack (2 x 10mg) is from a single verified batch. COAs are available for download on the product page or on request.

Can I buy Melanotan II 20mg in the UK for research?

Melanotan II occupies a complex regulatory position in the UK. The MHRA classifies Melanotan products as medicinal products requiring marketing authorisation under the Human Medicines Regulations 2012, which MT-II has not obtained. No Melanotan product holds a marketing authorisation for use in the UK. Sempica supplies MT-II exclusively as a research-grade compound for qualified laboratory researchers conducting in vitro and preclinical scientific studies. All purchases are subject to compliance with applicable UK and local research regulations. Researchers should verify their institutional and jurisdictional compliance requirements before purchase. MT-II is not sold for human or animal administration.

What melanocortin receptors does Melanotan II interact with?

Melanotan II is a non-selective melanocortin receptor agonist with binding affinities (Ki): MC1R: 0.67 nM (pigmentation and melanogenesis), MC4R: 6.6 nM (neuroendocrine regulation, metabolic and cardiovascular pathway research), MC3R: 34 nM (energy balance and appetite signalling), MC5R: 46 nM (peripheral tissue signalling). MT-II's broad receptor affinity makes it a valuable reference compound for whole-system melanocortin pharmacology research, distinguishing it from more selective agonists like afamelanotide (MC1R-selective) or PT-141 (MC3R/MC4R-biased).

How should Melanotan II 20mg be stored?

Storage guidelines for lyophilised Melanotan II vials: Before reconstitution: store at -20°C for long-term stability, or 2–8°C for up to 3 months. After reconstitution: store at 2–8°C and use within 30–45 days. Do not freeze reconstituted solution. Protect from direct light and moisture at all times. Avoid repeated freeze-thaw cycles. Both vials in the 20mg pack should remain sealed until use to maximise shelf life.

How is Melanotan II reconstituted for laboratory research use?

For in vitro laboratory use, Melanotan II lyophilised powder is reconstituted with bacteriostatic water. Standard protocol: (1) Allow vial to reach ambient temperature (20–22°C) for 5–10 minutes. (2) Inject 1ml bacteriostatic water slowly against the glass wall. (3) Gently swirl — do not vortex. (4) MT-II should dissolve to a clear, colourless solution. (5) Store reconstituted at 2–8°C. Suggested reconstitution: add 1ml bacteriostatic water for 10mg/ml concentration per vial. All handling must use aseptic laboratory technique.

What is the legal status of Melanotan II in the UK?

Melanotan II is NOT MHRA-approved in the UK for any medicinal, cosmetic, or human-use indication. The MHRA considers Melanotan products to be medicinal products under the Human Medicines Regulations 2012. No Melanotan product holds a marketing authorisation for use in the UK, and advertising, sale, or supply for human use is in breach of regulatory requirements. The MHRA has taken enforcement actions including website shutdowns and product seizures. Sempica supplies MT-II strictly for in vitro laboratory and scientific research use only. Researchers must verify their institutional and jurisdictional compliance requirements before purchase.

What research applications use Melanotan II?

In controlled laboratory and preclinical settings, MT-II is studied for: (1) Melanogenesis Research — MC1R activation in melanocyte models, studying melanin synthesis pathways and tyrosinase regulation. (2) Neuroendocrine and Metabolic Research — MC4R-mediated signalling for appetite, energy expenditure, and hypothalamic pathway research. (3) Receptor Pharmacology — reference compound for melanocortin receptor binding assays and selectivity profiling. (4) Cardiovascular Research — MC4R agonism studies for blood pressure modulation in preclinical models. (5) Thermogenic Research — MT-II has been studied for thermogenic activity and metabolic effects in animal models. (6) Anti-inflammatory Research — atherosclerotic plaque and anti-inflammatory cytokine research. All applications are in vitro and preclinical research contexts only.

What is the relationship between Melanotan II and PT-141?

PT-141 (Bremelanotide) is the direct descendant compound of Melanotan II. PT-141 was developed by modifying MT-II's structure to reduce MC1R-mediated melanogenic activity while preserving central melanocortin effects via MC3R/MC4R. Key structural difference: MT-II has a C-terminal amide (-NH2) while PT-141 has a C-terminal hydroxyl (-OH), shifting the receptor activity profile. MT-II remains the broader-spectrum whole-system reference compound, while PT-141 is the more target-selective descendant. PT-141 achieved FDA approval as Vyleesi in 2019.

Does this product include a Certificate of Analysis (COA)?

Yes. The Melanotan II 20mg pack is supplied with a batch-specific Certificate of Analysis (COA) covering both vials. Each COA confirms: HPLC purity results (≥99%), mass spectrometry molecular weight confirmation (1024.2 g/mol), peptide identity verification, and appearance data. COAs are batch-specific and traceable. Mass-spec verification at 1024.2 g/mol is essential to confirm compound identity — without it, distinguishing genuine MT-II from cheaper related melanocortin compounds is not possible.

Does Sempica ship Melanotan II to the UK?

Sempica ships research-grade compounds to qualified laboratory researchers in the United Kingdom with tracked, temperature-protective delivery. All peptide shipments are packaged to preserve lyophilised compound stability during transit. EU-partnered sourcing ensures supply chain reliability and batch traceability. All UK research compound supply is framed strictly for qualified in vitro laboratory and scientific research use, in compliance with applicable UK research regulations. Researchers should verify their institutional and jurisdictional compliance requirements before ordering. MT-II is not supplied for human or animal administration.

Why choose the 20mg pack over the 10mg single vial?

The 20mg pack (2 x 10mg) offers several advantages for laboratory researchers: (1) Research continuity — sufficient material for multi-phase experimental protocols without reordering. (2) Batch consistency — both vials are from the same verified synthesis batch, ensuring consistent purity and identity across experiments. (3) Value — 20mg packs offer better per-mg pricing vs single 10mg vials. (4) Storage flexibility — each vial remains individually sealed until needed, preserving the second vial's integrity while the first is reconstituted and used.

What safety considerations apply when handling Melanotan II?

When handling Melanotan II in laboratory settings, researchers should observe standard peptide safety protocols: (1) Use PPE — nitrile gloves, lab coat, eye protection. (2) Handle in designated research-grade work area. (3) Follow institutional biosafety guidelines. (4) Consult the compound's Safety Data Sheet (SDS) before use. (5) Label reconstituted vials with date, concentration, and researcher initials per SOP. In preclinical research literature, commonly reported biological effects include nausea, flushing, and cardiovascular observations. MT-II is not approved for human administration by the MHRA, FDA, or EMA.

Melanotan II 20 mg

Name: Melanotan II (MT-II) 20mg Research Peptide — Lyophilised | Sempica
Brand: Sempica
SKU: SEMPICA-MT2-20MG
Price: 59.99 GBP
Availability: InStock

Melanotan II 20 mg

£129.00

For researchers interested in melanocortin signalling and pigmentation-related laboratory research, Melanotan II 20 mg offers a clearly defined and consistently prepared research material.

Order Melanotan II 20 mg Research Pen Online

Category Skin & Hair

A synthetic melanocortin peptide used in laboratory research exploring pigmentation and melanocortin signalling

Melanotan II 20 mg from SEMPICA HEALTHCARE is supplied as a laboratory-prepared research material, presented in a sealed pen format with a fixed and clearly defined composition. It is intended solely for research and development purposes and is provided without instructions, protocols, or advice.

This product is not a medicine, not a treatment, and is not intended for human or animal use. By purchasing, you accept full responsibility for how it is stored, handled, and used within your own research setting.

What Melanotan II Is (Explained Simply)

Melanotan II is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). It is designed to interact with melanocortin receptors, a family of receptors studied for their role in pigmentation and broader central signalling pathways.

In simple terms, Melanotan II is researched because it helps scientists understand how melanocortin signalling influences melanin-related processes. This is why it frequently appears in laboratory work examining pigmentation pathways, including research contexts where skin response to ultraviolet exposure is being studied.

Why Melanotan II Is Studied

Melanotan II has been examined in laboratory research relating to:

Melanocortin receptor signalling behaviour
Pigmentation and melanin synthesis pathways
Cellular response to ultraviolet exposure
Central melanocortin system interactions
Receptor binding and selectivity studies

Published research has reported notable observations in pigmentation and melanocortin-focused studies, which is why Melanotan II continues to attract attention in academic and laboratory settings, including controlled investigations linked to tanning-related biology.

These findings are referenced only to explain research interest.
They do not relate to this product being sold and do not imply any effect, outcome, or intended use.

How Melanotan II Differs From Other Peptides

Unlike metabolic or endocrine regulatory peptides, Melanotan II is primarily studied for its receptor-specific activity within the melanocortin system.

Researchers are particularly interested in:

How melanocortin receptors respond to synthetic analogues
Differences between pigmentation-focused peptides and metabolic compounds
The relationship between receptor activation and melanin-related signalling
How central and peripheral melanocortin pathways interact

This places Melanotan II within targeted receptor and pigmentation research, rather than broad metabolic or regenerative studies.

Why a 20 mg Format Is Used

The 20 mg Melanotan II format is commonly chosen for:

Receptor-focused laboratory studies
Short-to-medium duration research cycles
Comparative work with other melanocortin peptides
Laboratories exploring pigmentation signalling across multiple observations

It provides a practical research quantity without introducing unnecessary complexity.

How This Product Is Supplied

SEMPICA HEALTHCARE supplies Melanotan II 20 mg as:

A laboratory-prepared liquid solution
Pre-mixed in 3 ml bacteriostatic water
Sealed in a pen format for controlled handling
Clearly labelled with known content and volume

This removes the need for manual preparation and reduces variability between research runs.

Technical Information

Compound name: Melanotan II
Category: Synthetic melanocortin peptide (research grade)
Molecular type: α-MSH analogue
Purity: ≥ 99 %
Net content: 20 mg
Solvent: 3 ml bacteriostatic water
Appearance: Clear liquid
Solution colour: Clear
Format: Factory-sealed research pen

This information is provided so purchasers know exactly what the compound is.

What Is Included

Each Melanotan II 20 mg Research Pen includes:

One pre-mixed Melanotan II 20 mg research pen
Individually sealed microneedles (research handling only)
Alcohol swabs
Printed storage and preservation notes

No instructions, dosing guidance, or research protocols are supplied.

Storage and Preservation Notes

Store refrigerated when not in use
Do not freeze
Avoid direct or indirect sunlight
Keep sealed when not being handled
Inspect visually; solution should remain clear

These notes exist only to help preserve material integrity, not to guide use.

Related Research Products

Melanotan II is often purchased alongside other research materials such as Melanotan I, DSIP, GHK-Cu, or SS-31 to support broader neuro-pigmentation and signalling research work.

SEMPICA HEALTHCARE does not recommend combinations or provide guidance. All decisions remain with the purchaser.

About SEMPICA HEALTHCARE

SEMPICA HEALTHCARE supplies clearly described, laboratory-prepared research materials for buyers who value transparency, consistency, and straightforward information.

We provide the product.
How it is used is entirely your responsibility.

Important Research Use Notice

This product is supplied strictly for research and development purposes only.

It is not intended to:

Diagnose, treat, cure, or prevent any disease
Be used on or by humans or animals
Be represented as a medicine, supplement, or injectable product

SEMPICA HEALTHCARE provides no guidance, plans, protocols, or advice beyond the information published here.

By purchasing, you confirm that you accept full responsibility for use, storage, handling, and regulatory compliance.

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Melanotan II 20 mg

Melanotan II 20 mg

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